Whole-genome sequencing analysis from samples of patients with RB and normal controls showed that the tumors contained a small number of mutations or chromosomal rearrangements; more likely, RB1 mutation causes epigenetic abnormalities in cancer-related genes, namely, the high expression of spleen tyrosine kinase (SYK), suggesting the regulation of RB and SYK is closely related [83]. Here, RB1 is linked to retinoblastoma.