None of the probands with PPCD3 demonstrated the minor allele of either single nucleotide polymorphism, although the 0% prevalence was not statistically significantly less than the 12.4% prevalence of the haplotype in the general population (data from HapMap; binomial proportion test p=0.19) or the 19.3% prevalence in probands with PPCD in whom ZEB1 coding region mutations were not identified (Fisher exact test p=0.16). The gene discussed is ZEB1; the disease is posterior polymorphous corneal dystrophy.