To address the relationship between FKBP51, stemness, and metastasis in melanoma patients, we performed double immunochemical staining of FKBP51 and nestin, an intermediate filament expressed in the cytoplasm of neuroepithelial stem cells35 in a series of 10 primary cutaneous and 20 brain melanoma metastases. This evidence concerns the gene FKBP5 and melanoma.