Although there is a paucity of knowledge regarding the role of PON‐1 across the spectrum of CKD, its role in chronic renal failure and ESRD has recently been reviewed.25 Indeed, PON activity and expression is lower in patients with ESRD,26–27 a finding that has been repeated in multiple ESRD cohorts.28–30 Not only does hemodialysis increase the antiinflammatory activities of HDL,31 but also increases in PON‐1 activity are observed after long‐term hemodialysis,32 suggesting that uremic toxins may play a mechanistic role in the suppression of PON‐1 activity. This evidence concerns the gene PON1 and chronic kidney disease.