CASP1 and silicosis: NALP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome components, caspase-1 and IL-1β, are also required for silicosis [142,151-153] and our preliminary findings indicate that caspase-1 is required for autoantibody induction (Kono and Pollard, unpublished observations).