Interestingly, TLR deficiency differentially affects lupus-specific autoantibody production, with absence of TLR7 or TLR9 reducing anti-ribonucleoprotein responses but not anti-DNA [94,95] whereas lack of TLR4 reduced production of both anti-ribonucleoprotein and anti-DNA autoantibodies [95]. This evidence concerns the gene TLR7 and systemic lupus erythematosus.