In vivo, for the chFab 14C5 fragment, the peak tumor-to-blood ratio (0.9) was reached at 6 h p.i. After 24 h the Fab was largely cleared from the system, which makes it an interesting probe for RID, despite high non-specific kidney uptake caused by renal clearance of the small fragment (<60 kDa). The gene discussed is FANCB; the disease is neoplasm.