Since recently reported trials [39,40], show that ipilimumab can safely be administered in combination with immunotherapy to men with prostate cancer, it seems logical to consider the initiation of future trials in which anti-CTLA-4 is combined with GVAX immunotherapy and low-dose cyclophosphamide, most likely in the earlier stages of metastatic disease. Here, CTLA4 is linked to metastatic neoplasm.