Similarly, in women with normal pregnancy who had high PAPP-A (NlPreg-HighPAPPA), 1st trimester sFlt-1 did not differ significantly from women with high PAPP-A levels who later developed preeclampsia (PE-HighPAPPA), 6.9 ± 4.0 vs. 8.8 ± 3.2 ng/mL respectively. The gene discussed is PAPPA; the disease is preeclampsia.