• Report of any of the following health problems: heart condition, chest pain during periods of activity or rest, loss of consciousness, diabetes treated with insulin or medications that may cause hypoglycemia, active tuberculosis, HIV, acromegaly, Cushing’s syndrome, chronic hepatitis B or C, inflammatory bowel disease requiring treatment within the past year, thyroid disease, renal disease, liver disease, hospitalization for asthma in the past year, or cancer within the past 5 years (except for non-melanoma skin cancers or early stage cervical cancer) or chronic use of steroid medication. The gene discussed is INS; the disease is Cushing syndrome.