Knock-down of DR5 expression did not affect the apoptotic response of ABC cells to TQ treatment as assessed by annexin v/PI dual staining (Figure 6C) nor did it affect the activation and cleavage of caspases-8, -3 and PARP (Figure 6D) suggesting that DR5 does not play a role in TQ-induced apoptosis in ABC cells. This evidence concerns the gene ANXA5 and aneurysmal bone cyst.