Even if this is the first report of such mechanism in cystic fibrosis (and more extensively in classic mendelian inherited diseases) similar mechanisms are becoming increasingly prevalent; in an attempt to find gene variants responsible for renal cell carcinoma (RCC), Wirsing et al. found that the rs11574744 SNP in the 3′UTR region of the HNF4A gene leads higher levels of HNF4A protein by destroying a target site for miR-34a [12]. This evidence concerns the gene HNF4A and hereditary clear cell renal cell carcinoma.