Table 2 shows the expression of the IFN-α gene for the individual patients and Figure 4 presents the mean percent of gene expression at week 24 compared to the level prior to hCDR1 or vehicle treatment, at week 0 (defined as 100%; dotted line). As can be seen in Table 2 and Figure 4, treatment for 24 weeks with hCDR1 diminished significantly (p = 0.0005) the gene expression of IFN-α in the 5 treated patients. No significant effects were observed in the 4 lupus patients that were treated with the vehicle alone (placebo group; Table 2, Figure 4). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.