Three of these loci, located on chromosome 9q21.32 near the FRMD3 gene, chromosome 11p15.4 at the CARS gene, and chromosome 13q33.3 at the MYO16/IRS2 locus, have since been confirmed in multiple diverse collections of unrelated T1D or type 2 diabetic (T2D) patients [18], [20], [22]. This evidence concerns the gene IRS2 and type 2 diabetes mellitus.