In full adjusted model 2 after considering age, BMI, personal habits (smoking, alcohol drinking, and betel quid chewing), SHBG and above 4 factors (adiponectin, leptin, E2 and 1,25(OH)2D3), E2 (beta = −0.216, P<0.001) and 1,25(OH)2D3(beta = 0.067, P = 0.045) were still indepndent predictors of MetS, in addition to adiponectin (beta = −0.259, P<0.001) and leptin (beta = 0.086, P = 0.007) (Table 3). Here, LEP is linked to metabolic syndrome.