In HeLa cells, more extensive co-localisation of AnxA2 and EEA1 was observed, possibly due to the increased Tyr23 phosphorylation of AnxA2, which is a typical feature of cancer cells such as HeLa [62] and Tyr23 phosphorylation of AnxA2 is essential for its proper endosomal association [63]. The gene discussed is ANXA2; the disease is cancer.