In addition, VEGF induces Tyr phosphorylation and nuclear translocation of Activator of Transcription 6 (STAT6) [69], which interacts with AnxA2 in prostate cancer cells [70], suggesting that one of the angiogenic effects of VEGF is to regulate the expression of AnxA2 directly or indirectly. Here, ANXA2 is linked to prostate carcinoma.