And we selected SNPs located in various miRNAs, including miRNAs which regulate breast cancer-associated genes, such as RAS, PTEN, ATM and BRCA1/2 (hsa-mir-149, hsa-mir-196a-2, hsa-mir-30c-1, hsa-mir-146a, hsa-let-7f-2); miRNAs regulating breast cancer associated receptors ER, PR and HER2 (hsa-mir-27a, hsa-mir-125b-1, hsa-mir-105-1, hsa-mir-105-2); and miRNAs closely associated with breast caner invasion and metastasis (hsa-mir-373 and hsa-mir-10b). The gene discussed is ESR1; the disease is breast carcinoma.