Besides, the Hh–Gli signaling interacts with other signaling pathways in bidirectional and context-specific ways, and several lines of evidence suggest that the context-dependent regulation of the Gli code by oncogenes and tumor suppressors constitutes a basis for the widespread involvement of Gli1 in human cancers, this protein supporting tumor progression and metastatic transition [6], [7]. The gene discussed is GLI1; the disease is neoplasm.