Using candidate-gene positional cloning approach we have finely mapped genes vulnerable to schizophrenia in Taiwan, including DISC1 at chromosome 1q42 [36], RASD2 and CACNG2 at chromosome 22q12 [37], and DPYSL2, TRIM35 and PTK2B at chromosome 8p21 (in preparation). Here, PTK2B is linked to schizophrenia.