SOD1 and familial hypercholesterolemia: As shown in Tables 1, 2, 3 and Fig. 1, ARD rats exhibited increased SBP, accelerated renal blood flow, increased uALB, plasma cholesterol, LDL-cholesterol and TBARS, and decreased SOD activity as compared with CTL rats, indicating that ARD rats were characterized by renovascular stenosis, hypercholesterolemia, increased oxidative stress, impaired antioxidant capability, and albuminuria.