In melanocytes isolated from vitiligo patients we observed chronic activation of Nrf2, manganese superoxide dismutase 2 (SOD2), hemeoxigenase-1 (HO-1), NAD(P)H deydrogenase quinone-1 (NQO1) and catalase genes expression that indicated a compromised redox homeostasis (Fig. 1A). The gene discussed is HMOX1; the disease is vitiligo.