However, the capacity to suppress infection of CD8+ T cells from PHI patients for whom viral replication in CD4+ T cells after HIV-1 BaL superinfection in vitro was at least three times the one in non superinfected CD4+ T cells (superinfection index >3) (n = 29) (0.2 [0.05–0.42] log p24 decrease CD4 vs CD4:CD8 1:1) was still much weaker than the responses observed in HIC (p<0.001) (not shown). Here, CD4 is linked to infection.