Coupled with diverse and heterogenous functional responses associated with CXCR4 and CXCR7 stimulation, including regulation of cell growth, migration, sphere formation, and tube formation, our results suggest that the CXCL12-CXCR4-CXCR7 system possesses the potential for considering personalized targets for human GBM therapy. This evidence concerns the gene CXCL12 and glioblastoma.