MAPT and dementia: In humans, closed-head TBI (typically a blow to the head) has been reported to cause small-vessel haemorrhages (petechial bleeding) [47], [48], and to be associated with the deposition of Aβ and/or the formation of plaques [40], [41], [42], [43], [49], [50], [51], [52], [53], hyperphosphorylated tau [35], [54] and dementia [55], [56], [57].