Our results in GSK0660-treated septic rats suggest that the role of the GR in sepsis-induced PPARβ/δ activation does not depend on the increased levels of the GR in septic muscle but may reflect other mechanisms, such as an increased protein-protein interaction between the GR and PPARβ/δ as suggested by results in dexamethasone-treated myotubes. The gene discussed is NR3C1; the disease is Sepsis.