In previous studies, sepsis in rats was associated with increased expression of the GR in skeletal muscle [57] and sepsis-induced muscle wasting as well as expression of atrogin-1, MuRF1, and FOXO1 were prevented by treatment with the glucocorticoid receptor antagonist RU38486 [12], [35], [38], [39]. The gene discussed is TRIM63; the disease is Sepsis.