A simple system for in vitro ECM modelling is a solubilised basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in extracellular matrix proteins comprising laminin, collagen IV, heparin sulphate proteoglycans and entactin/nidogen [9]–[18]. The gene discussed is LAMB2; the disease is neoplasm.