Interestingly, whereas LIC-pIC induction of IFNL1 mRNA and IFN-λ1 protein was weaker in MRC-5 cells than in HepG2 cells, the levels of IFNL1 mRNA and IFN-λ1 protein in MRC-5 cells were almost comparable to those seen in HepG2 cells upon infection with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV) (Figure 4C and 4D). The gene discussed is IFNL1; the disease is infection.