It is widely accepted that tumors escape from immune surveillance through several intrinsic mechanisms, including the weak immunogenicity of tumor antigens [12], down-regulation of major histocompatibility complex (MHC) molecules on tumor cells[13]–[14], defects of antigen processing machinery [13], [15] or the release of immuno-suppressive molecules[16]–[17]. This evidence concerns the gene HLA-C and neoplasm.