VEGFA and malignant colon neoplasm: In addition, our findings that, in MR-transfected colon cancer cells, KDR expression was significantly decreased by MR activation indicated that activated MR can inhibit also the expression of the receptor 2 of VEGFA, thus strengthening the hypothesis of a causal relationship between MR underexpression and KDR overexpression found in CRC by Di Fabio and collaborators.