Using an original in vitro model based on a colon cancer cell line ad hoc ingenierized to express high levels of agonist-regulated MR, we showed that the expression of an active MR is causally linked to a decrease in the expression of VEGFA, which sustains angiogenesis, critical for growth and progression of solid tumors in a hypoxic environment. This evidence concerns the gene NR3C2 and malignant colon neoplasm.