[22] This notion is consistent with recent reports that showed that, in lung tumors, MR expression levels comparable to those found in normal lung tissue positively correlate with patients overall survival time. [23] In addition, the study in CRC showed that MR underexpression is associated with VEGF receptor 2/KDR overexpression and suggested that underexpression of MR may play a role in the pro-angiogenic switch of the tumor. [22] However to date there has been no mechanistic explanation to this correlation. This evidence concerns the gene KDR and neoplasm.