We make the analogy between restricted of ADAMTS-13 activity (allowing some ULVWF strings to remain uncleaved for our studies) and TTP or other thrombotic microangiopathies with ADAMTS-13 activity that may be inadequate for the rate of EC-secretion/anchorage of ULVWF strings (augmented by cytokines in infection or inflammation). This evidence concerns the gene ADAMTS13 and thrombotic thrombocytopenic purpura.