EGFR and neoplasm: When Puyo et al. [49] analyzed the association between specific EGFR functional polymorphisms and anticancer drug activity in 60 human tumor cell lines established by the National Cancer Institute, the frequency of the nonsynonymous SNP rs28384375 (also designated as Val592Ala) was 0.5, while the heterozygous frequency of the −216G>T SNP (also designated as rs287129) was 0.346.