Many reports suggested that several EGFR SNPs, including rs2227983 (also designated as Arg521Lys or R497K) [39], [52], [53], rs1050171 (also designated as Q787Q) [54], [55] and rs2293347 (C2982T) [56], were more likely to affect the biological behavior of tumors (such as tumor growth, invasion, metastasis, and progression) than to define susceptibility to cancer development. This evidence concerns the gene EGFR and neoplasm.