In concert with these results, the amount of cIAP2 protein was markedly and significantly decreased in RPMI-8226, U266 and LP1 cells infected with a lentivirus carrying a shRNA directed against RelB compared to what is seen in the empty-virus-infected cells (Figures 3H and 3I), thus strengthening the observations made in MM patient samples (Figures 2A and 2B). This evidence concerns the gene BIRC3 and Miyoshi myopathy.