NFKB1 and cancer: Aberrant NF-κB activity has been observed in many cancers, including both solid and hematopoietic malignancies, and sustained activation of NF-κB can affect all six hallmarks of cancer [38], including insensitivity to growth inhibitory signals, evasion of apoptosis, induction of angiogenesis, and metastasis [8], [39]–[41], thus leading to the concept of NF-κB addiction in cancer cells.