MLH1 and colorectal carcinoma: The MLH1 promoter methylation in female and male were 20.8% (95% CI: 15.6–27.2%) and 11.8% (95% CI: 6.9–16.5%) in total CRC group (pooled OR = 1.641, 95% CI = 1.215–2.215; P = 0.001; I2 = 33.819%) (Table 1 and Table 3).