The largest population-based study [21] observed similar results, the frequencies of MLH1 promoter methylation were 46.8% (51/109) in BRAF mutated CRC and 17.4% (97/559) BRAF wild type CRC (P<0.001); whereas, they were 15.5% (40/258) in KRAS mutated CRC and 26.2% (112/428) KRAS wild type CRC (P = 0.001). The gene discussed is MLH1; the disease is colorectal carcinoma.