In addition, for the 10 studies [16], [22], [53], [54], [57], [59], [60], [61], [62], [63] that provided both MSI and MSS status in total CRC, the pooled OR for the association between MLH1 promoter methylation and MSI status (MSI vs. MSS) was 27.096 (95% CI: 13.717–53.526; P<0.001; I2 = 59.001%; Table 3, Figure S1). The gene discussed is MLH1; the disease is colorectal carcinoma.