MLH1 and colorectal carcinoma: For the three studies that provided both MSI-H and BRAF mutation status in CRC, the pooled OR for the association between BRAF mutation status and MLH1 promoter methylation was 37.615 in MSI-H CRC (95% CI: 10.011–141.311; P<0.001; I2 = 0.000%) (Table 3).