For tumors with MLH1 protein expression, MLH1 promoter methylation was detected in 11.9% (95% CI: 1.5–53.8%) of the 67 total CRC and in 9.8% (95% CI: 3.4–25.2%) of the 308 sporadic CRC (P = 0.862; Table 2). The gene discussed is MLH1; the disease is colorectal carcinoma.