The pooled prevalence of MLH1 promoter methylation in 138 BRAF-mutated and 764 BRAF wild type CRC was 53.2% (95% CI: 27.7–77.2%) and 13.7% (95% CI: 5.1–32.0%) in three studies (pooled OR = 9.419; 95% CI: 2.613–33.953; P = 0.001; I2 = 67.030%) (Table 2 and Table 3). This evidence concerns the gene MLH1 and colorectal carcinoma.