One approach utilizes the testing of biochemical markers of liver fibrosis: hyaluronic acid [8], [28], adiponectin [11], high-sensitivity CRP [9], type IV collagen [8], serum IL-6 [10], leptin [28], laminin [8], [28], c-peptide [7], and cytokeratin-18 [29], [19]. This evidence concerns the gene ADIPOQ and Hepatic fibrosis.