CCR7 and HIV infectious disease: It has previously been speculated for HIV infection, where this phenomenon also has been observed, that the antigen-specific T-cells with cell-surface expression of both CD45RA and CCR7 might represent effector memory cells that reverted back to a ‘naïve’ like phenotype without losing this subset's ability of proliferation upon antigen-stimulation [45], yet it may also be due to increased lymphopoiesis in patients with active TB.