C10orf116/APM2 expression has been implicated in other gynecological cancers; for instance, is has been shown to strongly differentiate between the BRCA1 associated breast tumor subclasses ESR1-positive and ESR1-negative [20] and is has been found to be downregulated in utering cancer in a number of studies [21]. The gene discussed is ADIRF; the disease is female reproductive organ cancer.