The top two associations found for prostate cancer were for rare NS variants in F13A1 (rs140712764, Val170Ile, OR = 28.0, p = 9.1×10−7) and ANXA4 (rs146778617, Val315Phe,OR = 4.52, p = 6.0×10−6), Table 4, see also Table S2. This evidence concerns the gene ANXA4 and Familial prostate cancer.