For breast cancer, we analyzed 11 genes and did not observe an over-representation of associations at p<0.05 in any gene (observed/tested: ATM, 3/62; BRCA1, 2/42; BRCA2, 3/80; BRIP1, 0/16; CHEK2, 0/8; NBN, 3/17; PALB2, 1/26; PTEN, 0/1; RAD50, 3/24; STK11, 1/4; TP53, 0/4), or any significant associations (p<0.05) from gene-based burden testing. The gene discussed is CHEK2; the disease is breast cancer.