When the analysis was restricted to advanced prostate cancer, four gene burdens (for SAMD1, FOXF2, NOL4 and CPA3) were significant using the score test but not by exact logistic regression (p = 2.5×10−3 , 3.3×10−3 , 5.0×10−3 and 3.4×10−6 respectively). The gene discussed is FOXF2; the disease is Familial prostate cancer.