Previous reports [24], [39] have highlighted the NS SNP rs17632542 in KLK3 as highly associated with PSA level and a highly significant risk variant in fine-mapping of the locus near rs2735839 [39]; while no report for prostate cancer exists for coding SNPs in RTEL1, another NS SNP, rs3208008, in RTEL1 has been found to be associated with glioma risk [40]. Here, KLK3 is linked to Familial prostate cancer.