INS and Familial prostate cancer: Other coding SNPs that could include causal variants producing synthetic associations (associations of rare with common SNPs of high penetrance) include SNPs in genes INS-IGF2, ZFYVE26, C16orf46, UNC13A, NRIP1 and CCDC91 for breast cancer and SNPs in SNED1 and PASK for prostate cancer.