MC1R and melanoma: Consistently, a relationship between the MC1R loss-of-function ‘R’ alleles (D84E, R142H, R151C, I155T, R160W, and D294H) and risk of cutaneous basal cell carcinoma (OR 1.37–3.16), SCC (OR 1.99) and melanoma (OR 1.38–4.64) has been shown (reviewed in [54]).