CD8A and hemorrhagic fever with renal syndrome: However, the present finding that hantaviruses efficiently inhibit cytotoxic lymphocyte-mediated killing of infected cells, together with reports that infected endothelial cells in patients are not damaged [4], [10]–[12], and the demonstration that CD8 T cells are not involved in ANDV-induced pathogenesis in a Syrian hamster model [44], suggests that HFRS/HCPS-pathogenesis is not directly caused by cytotoxic lymphocyte-mediated killing of infected cells.