CD81 and infection: Lentiviral expression of an shRNA targeting OCLN in HepG2+miR-122+CD81 cells efficiently silenced expression of endogenous OCLN (Figure 4A) and impaired infection with both HCVpp and HCVcc bearing the glycoproteins from the H77 genotype 1a and HC-J6 2a isolates, respectively (Figure 4B).