However, the role of NF-κB in liver carcinogenesis is complex, as it inhibits cell death-promoted tumorigenesis [25], [48], [49], while promoting inflammation-driven tumor-formation in Mdr2-deficient [33] and in LT-transgenic mice [21] and in xenografts of human HCC [50]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.