The results showed that eIF4GI cleavage appeared at 6 h after EV71 infection when VP1 protein was expressed at a low, not detectable level; in contrast, PABP and MAVS cleavage was observed at a later time point, at 12 h, when VP1 was abundantly expressed during infection (Supplemental Figure S3B). This evidence concerns the gene EIF4G1 and infection.