To test whether EV71-induced MAVS cleavage is associated with cellular apoptosis and activated caspases, we first examined whether caspase activation occurred after EV71 infection in HeLa cells by western blot analysis of pro-caspase 3, 8, 9, PARP, and EV71-VP1 during an infection time course. The gene discussed is CASP3; the disease is infection.