In the present work, we analyzed the effect of PPAR's agonists during the early-time infection of J774A.1 macrophages with L. mexicana and addressed the issue of whether the addition of PPAR agonists to J774A.1 macrophages infected with L. mexicana could increase ROS production by polarization of M2 towards M1 macrophages, inhibiting cPLA2 and COX-2 enzymes. This evidence concerns the gene PLA2G4A and infection.