IL1B and infection: In summary, PPAR agonists and cPLA2 antagonist set down the levels of IL-10; at the same time they upregulated TNF-α, IL-1β, and IL-6 cytokines, or at least they were held overexpressed after infection as occurred with nontreated infected macrophages (Supplementary Figure 2), all together are evidence of a possible M2 to M1 polarization.