Since BALB/c mice macrophages can fully support maturation of alternatively activated macrophages, J774A.1 macrophages were incubated with PPAR agonists and cPLA2 antagonist, and then infected or stimulated with LPS and zymosan; neither infection nor treatments induced MR expression, an M2 receptor classified as an alternative activation marker (Supplementary Figure 3); however, PPAR agonists and cPLA2 antagonist induced an increase of TLR4 expression at 60 and 120 min after infection (Figure 3), an M1 receptor classified as classical activation marker. The gene discussed is PLA2G4A; the disease is infection.