These findings are of major importance in the light of recent large multicentric studies aiming at tight glucose control, which were discontinued due to excessive risk of hypoglycemia—the Glucontrol and the VISEP study [5, 7]—and particularly the NICE-SUGAR trial, where intensive insulin treatment targeted at normal glycemic levels was associated with an increased risk of hypoglycemia and overall mortality [6]. The gene discussed is INS; the disease is Hypoglycemia.