In HAdV-C5-infected cells, only two common up- or downregulated cellular proteins were observed at 24 h post infection, sequestosome-1 (SQSTM1, also known as ubiquitin binding protein p62) involved in the NFκB pathway [48] and heat shock 70 kDa protein 1A/1B (HSPA1A), an ATP-dependent molecular chaperone (S Table 2). Here, SQSTM1 is linked to infection.