CD8A and Hepatic fibrosis: Indeed, we found increased effector CD8+ T-cell frequencies in patients with F3–F4 liver fibrosis in both HCV monoinfected patients (median 41.3% versus 21.7% in patients with F0–F2 liver fibrosis) and HIV/HCV-coinfected patients (33.2% versus 25.0%; p<0.01) (Fig. 3D).