[21] Therefore, we examined whether HIV/HCV-coinfection drives changes in memory and effector phenotype of CD8+ T-cells, by studying percentages of naïve (CD45RO−CD27+), central memory (CD45RO+CD27+), effector memory (CD45RO−CD27+) and effector (CD45RO−CD27−) CD8+ T-cells. Representative plots of a healthy control, an HCV monoinfected patient and an HIV/HCV coinfected patient are shown in figure 3A. This evidence concerns the gene CD27 and coinfection.