ADORA2A and acute respiratory distress syndrome: When observing the effect of SIN (120 mg/kg) on lung damage in A2AR KO mice suffering from LPS-induced ALI, there was no significant difference in the lung water content (Figure 5A), P/F ratio (Figure 5B) and histological signs of pulmonary injury (Figure 5C) between non-SIN-treated group and the SIN-treated group.