NPPB and heart failure: [2]. Additionally, the diagnosis of heart failure is supported by the laboratory analysis of natriuretic peptides such as NT-proBNP or BNP which reflect neurohormonal activation. The diagnostic value of these biomarkers is characterized by a high negative predictive value for the exclusion of LV dysfunction. Furthermore, the natriuretic peptide concentration in plasma/serum (particularly B-type natriuretic peptide, BNP) correlates with left ventricular (LV) function and mass [3], [4].