CD274 and infection: In contrast, we found that RRV infection of 12 week-old NOD mice did not significantly alter the frequency, numbers and PD-L1 expression of CD8αβ TCRαβ IEL at days 2, 5 10 and 21 post infection (p>0.05; Fig. S1), consistent with the lack of diarrhoea and reduced intestinal RRV replication in these older mice [9].