NDRG1 and acute myeloid leukemia: Generally, MYCN transcripts progressively decrease during the initial differentiation step into short-term HSCs (ST-HSCs) to ensure the expression of NDRG1. Tschan reported that significantly higher levels of NDRG1 mRNA were detected in granulocytes of healthy donors than in primary AML cells, moreover, silencing of NDRG1 diminished neutrophil differentiation of leukemic cell lines [29].