We report here a MYCN transgenic zebrafish model with a phenotype that recapitulates main aspects of human AML such as distorted proliferation, metabolic disturbance, increased myeloid cells and their precursors accumulation in peripheral circulation, spleen and kidney marrow, suggesting that MYCN plays a role in the etiology of AML. The gene discussed is MYCN; the disease is acute myeloid leukemia.