In the LNCaP prostate cancer cell line, up-regulation of TRPV6 augments proliferation and cell survival while retarding apoptosis through a mechanism that appears to involve activation of the nuclear factor of activated T-cell (NFAT) transcription factor [27]; reduction of TRPV6 with siRNA reduced proliferation and increased apoptosis. The gene discussed is TRPV6; the disease is Familial prostate cancer.